Tramadol and Motrin (ibuprofen) 

Tramadol and Motrin (ibuprofen) 

tramadol and ibuprofen


Physicians often recommend tramadol and ibuprofen (Motrin) for pain management. However, these two medicines are different and belong to other classes. They differ in their mechanism of action as well. Tramadol is an opioid analgesic drug that helps in relieving pain ranging from moderate to severe. On the other hand, ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It helps in anti-inflammation that occurs from the pain. 

A doctor may prescribe tramadol and ibuprofen together to manage the pain better. Taking these medications together can increase the risks of having specific side effects such as drowsiness, dizziness, nausea, etc. This is why it is essential not to exceed the dosage limit set by your doctor. It is necessary to follow the instructions because doctors often recommend dosages tailored to your needs. Because they will see your medical history before prescribing anything.



Tramadol belongs to a class of medications that are commonly known as opioid analgesics. Following are some of the uses of tramadol:

  • Tramadol is prescribed for various kinds of pain like post-operative pain, muscular pain, dental pain, and pain associated with conditions like arthritis, neuropathy, etc.
  • Tramadol is sometimes also used to treat pain in individuals who are suffering from cancer. It works to cure acute and severe pain when other medications fail.
  • When other non-opioid medications fail to treat chronic pain effectively, That's where tramadol comes in to treat chronic pain effectively.

Side effects:

It can cause side effects ranging from standard to severe if not used properly. Here are some of the common side effects of tramadol:

  • Nausea
  • Dizziness
  • Drowsiness
  • Headaches
  • Constipation
  • Fatigue

It can also cause some severe side effects like:

  • Seizures
  • Addiction
  • Respiratory depression (slowed breathing)
  • Serotonin syndrome (excessive serotonin in the brain) 


Tramadol is quite a powerful and highly effective drug. So, if you are taking any other medication, you must inform your doctors because tramadol can interact with other medicines to cause serious side effects. 

  • Tramadol with baclofen can cause respiratory depression, dizziness, and drowsiness. 
  • Tramadol and Percocet together can cause sedation and respiratory depression.
  • Tramadol with oxycodone can cause sedation and respiratory depression.
  • Taking tramadol with metaxalone can cause sedation, dizziness, drowsiness, and central nervous system depression. 
  • Tramadol and Advil (ibuprofen) together can cause gastrointestinal bleeding and ulceration. 
  • Tramadol can cause gastrointestinal bleeding and ulceration upon interacting with Motrin (naproxen)
  • Tramadol and Tylenol (acetaminophen) together can cause severe damage to the liver.
  • Respiratory severe depression and central nervous system depression symptoms can occur if tramadol interacts with benzodiazepines such as diazepam.
  • Tramadol can interact with quinidine to increase the risk of central nervous system depression systems.
  • Tramadol can also interact with cyclobenzaprine to increase the risk of central nervous depression. 

Motrin (ibuprofen):


Ibuprofen is a medication class used to relieve pain and inflammation. The following are the uses of ibuprofen:

  • It is often used to relieve moderate to severe pain in patients with arthritis, headaches, muscle aches, etc.
  • Ibuprofen also reduces fever caused by viral and bacterial infections.
  • It is used as a specialist for its anti-inflammation effect caused by arthritis. 
  • It is also used to treat migraine. 
  • Ibuprofen is also effective when used to treat injuries from accidents or sports. 

Side Effects:

Like any other medication, ibuprofen can cause side effects if not used properly. Here are some side effects that can occur:

  • Headaches
  • Dizziness
  • Upset stomach
  • Kidney problems
  • High blood pressure
  • Gastrointestinal ulcer
  • Allergy


Ibuprofen can interact with different medications and cause some profound negative implications.

  • Combining ibuprofen with baclofen can increase the risk of side effects and enhance its effects. It's important to consult with the doctor first.
  • Ibuprofen can increase the pain-relieving effects of oxycodone (opioid), but it can also increase the risk of causing dizziness, drowsiness, and respiratory depression.
  • Metaxalone is a muscle relaxant and can interact with ibuprofen to cause some severe side effects like respiratory depression, dizziness, and drowsiness. 
  • Taking ibuprofen with Tylenol (acetaminophen) can complement each other to relieve pain. However, contacting the doctor before taking these medicines together is still important. 
  • Taking ibuprofen with aspirin can decrease its cardioprotective effects. So, if you are taking aspirin for your heart, then it is essential to consult a healthcare professional.
  • Ibuprofen can increase the blood levels of lithium, which leads to lithium toxicity. 

Discussing your medical history with your doctors before taking medications is crucial. Because these medicines are effective but dangerous, their interactions can harm your health. Therefore, it is always recommended that you follow your doctor's instructions. 

Uses of tramadol and Motrin combination:

Following are some of the potential uses:

  • Although these medications have different mechanisms of action, they can provide enhanced pain relief. If either medicine alone does not cure moderate to severe pain, the combination is used to treat it
  • The combination of these medications helps in treating acute injuries effectively. Because these medications relieve not only pain but also reduce inflammation. 
  • This combination is also used in treating pain post-surgeries

It is important to note that this combination of medications should only be used after the recommendation of health care providers. And the instructions should be strictly followed. 

How does the combination help in anti-inflammation?

Ibuprofen is an NSAID that inhibits the production of prostaglandins, substances that contribute to inflammation and pain. When it lowers the production of prostaglandins, ibuprofen naturally helps reduce inflammation. 

When combined with tramadol, these two medications can provide enhanced anti-inflammatory effects. Tramadol helps treat pain, whether moderate or severe, while ibuprofen helps reduce inflammation. This dual-action approach can result in enhanced anti-inflammatory effects, which would be greater than the effects of either medicine alone. 

Please consult your doctors first because they will recommend the precise dosage to help achieve this effect. Of course, this means they will have access to your medical history and current health status to ensure that the dosage amount is precise. To avoid having severe side effects, follow their recommendations strictly. 

Side Effects of using tramadol and ibuprofen together?

Taking tramadol with ibuprofen has some benefits, but it can also have some side effects. 

  • Dizziness
  • Drowsiness
  • Headaches
  • Impaired cognitive functions
  • Indigestion
  • Upset stomach
  • Vomiting 
  • Nausea
  • Abdominal pain
  • Stomach Ulcer
  • Sedation
  • High heart rate
  • High blood pressure
  • Allergy
  • Respiratory depression
  • Heart Attacks
  • Strokes

It is crucial to discuss the potential benefits and side effects of using tramadol and ibuprofen with a healthcare professional. After weighing the risks and benefits, they will prescribe the exact dosage necessary to achieve the desired outcome. 


Tramadol and ibuprofen can be used to treat different levels of pain, but it is crucial to consult a healthcare professional for guidance. The combination can provide enhanced relief from pain and anti-inflammatory effects. However, it should still be done carefully, as they can cause serious side effects as well.

It is essential to consult a doctor. After viewing and analyzing your current health, severity of pain, and medical history, they will be able to create a precise dosage schedule. It is advised to follow that schedule, and in case of any queries or experiencing side effects, report to your doctor immediately. 


Q: Can I take 800mg ibuprofen and tramadol? 

Ibuprofen 800mg is considered a high dosage and should only be taken after consulting with a healthcare provider. It is often prescribed for extreme situations and only for a limited period. 

Q: Can I take tramadol and ibuprofen 600 together?

Ibuprofen 600mg is also a high dose, and if you take it with tramadol, it can increase the risk of side effects and interactions. Both medications can cause gastrointestinal issues, such as stomach upset and bleeding, and combining them may further increase this risk. 

Q: What's the best pain reliever to take with tramadol?

The best pain reliever to use with tramadol depends on many factors, such as the individual's medical history, severity of pain, and current health status. Some pain relievers are used with tramadol, like Acetaminophen (Tylenol) and Nonsteroidal anti-inflammatory drugs (NSAIDs). 

Q: How do tramadol and ibuprofen be alternated?

Consult your healthcare doctor. Follow the recommended dosage schedule. Note potential interactions or changes. Monitor the pain relief performance. 

Q: Can I take paracetamol with tramadol?

Yes, you can take paracetamol with tramadol. It is often recommended that they be brought together. Both have different mechanisms to cure pain but complement each other. 

Q: What should you not take with tramadol?

Avoid using other opioids, sedatives, tranquilizers, hypnotics, alcohol, Monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRIs).

Q: Can you take tramadol and ibuprofen at the same time?

Although it is risky, they can be taken together under healthcare professionals' guidance. So, consult them first before consuming them.

Q: Can I take tramadol with Tylenol?

Yes, you can take tramadol with Tylenol. They are often used together for pain management. However, these combinations can be dangerous. Therefore, never use these medications on your own. Discuss it with your healthcare providers; they will prescribe the dosage and schedule. Strictly follow it.