Can I take tramadol and Naproxen together?

Can I take tramadol and Naproxen together?

tramadol and Naproxen


Tramadol and Naproxen are both used for pain relief. However, they function entirely differently. They can cause severe but different side effects. For instance, if you are not careful, take these two medicines together. It can increase the risk of causing drowsiness, dizziness and gastrointestinal bleeding. Therefore, it is not recommended to take tramadol and Naproxen together without consulting with your doctor. The doctor can assess your condition and make a plan for your medicines. 

Tramadol and Naproxen are taken together in the event that other pain relievers alone have failed to reduce pain effectively. Tramadol is an opioid pain reliever famous for reducing the perception of pain by binding to receptors in the brain. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain. 

Although they are effective, taking these two medicines together can cause some potential harm. Naproxen is an NSAID that can cause ulcers in the stomach, and tramadol can also cause stomach irritation, so the risk of gastrointestinal bleeding increases significantly. Tramadol has been reported to cause respiratory depression, and Naproxen can also cause respiratory depression. Consequently, the chances of respiratory depression also increase. There are other potential harms as well that can occur after you have taken these medicines. 

What is tramadol?

Tramadol is an opioid drug used to relieve acute to severe pain. It has a dual action mechanism: It works by binding itself to the receptors of the brain and spinal cord, reducing the perception of pain. Additionally, tramadol is responsible for the reuptake of serotonin and norepinephrine. Serotonin and norepinephrine both help regulate mood, anxiety, and pain. Tramadol's unique mechanism increases these effects.

Tramadol is often used in critical pain conditions like operations and cancer. Physicians have made two formulations of tramadol, and both have different dosages. They are immediate-release (IR) and extended-release (ER). As the names suggest, extended-release tramadol is given to the patient in multiple doses, and it takes more hours to perform its function correctly. In comparison, immediate release takes about 3-4 hours to do its job. 

Interaction of Tramadol with other medicines:

Tramadol is a highly effective drug. Therefore, it is recommended to consult with doctors first if you are taking other medications. It can interact with them to cause serious side effects. Here's what can happen if tramadol interacts with these medicines:

  • Tramadol can cause gastrointestinal bleeding and ulceration upon interacting with Motrin (Naproxen). 
  • Interaction of tramadol with oxycodone can cause respiratory depression and sedation. 
  • Tramadol and baclofen interact with each other to cause serious side effects like respiratory depression, drowsiness and dizziness.
  • If you take tramadol and Advil (ibuprofen) together, their interaction can also cause gastrointestinal bleeding and ulceration. 
  • Tramadol and Percocet interaction can cause sedation and respiratory depression. 
  • Taking tramadol and Tylenol (acetaminophen) together can cause severe damage to the liver if abused. 
  • Taking tramadol with metaxalone can cause sedation and drowsiness. 
  • Respiratory severe depression and central nervous system depression symptoms can occur if tramadol interacts with benzodiazepines such as diazepam. 
  • Tramadol can interact with quinidine to increase the risk of central nervous system depression systems. 
  • Tramadol can also interact with muscle relaxants like cyclobenzaprine to increase the risk of central nervous depression. 

If you are taking any of the above medicines, inform your health providers before taking tramadol. After inspecting your medical history and symptoms, they will recommend the right dosages. 

Opioid abuse:

Opioids are a class of drugs that relieve pain. They include medicines such as oxycodone, hydrocodone and fentanyl. They are highly effective in reducing pain. However, they also have a potential for being abused because opioids have a dependency problem. Opioid abuse is on the rise because it can be got through illegal activities like theft and the internet. 

Opioid abuse can cause a wide range of side effects like overdose, seizures and eventually death. It also affects society and economics. For instance, healthcare costs, crime, increased diseases, etc. Therefore, it is important to make people aware of opioid abuse and how it can be prevented. Healthcare professionals, government and local communities should work together to help reduce opioid abuse and promote improved health. 

What is Naproxen?

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and helps relieve pain and fever. It functions by decreasing the production of prostaglandins, which are responsible for pain and inflammation in the body. Naproxen is used to cure minor pain and fever, such as headaches, muscle pain, and menstrual cramps. It is also prescribed for severe pain, like arthritis and gout. 

It is generally available in tablet form and taken orally to be absorbed in the gastrointestinal tract. However, its duration of action is longer than that of other NSAIDs. Naproxen can also cause serious side effects, such as stomach pain, ulcers, and bleeding, to those who have stomach problems or who take it long-term. Therefore, it is essential to follow the instructions carefully after the recommendation of healthcare providers.

Interaction of Naproxen with other medicines:

Naproxen is an effective medicine, but it also comes with its side effects. Naproxen can interact with other medications to increase the risk of adverse effects. Following are some of the examples:

  • The use of Naproxen and corticosteroids (prednisone) can increase the risk of ulcers and gastrointestinal bleeding, which can be painful.
  • Taking Naproxen with other NSAIDs like aspirin can also cause ulcers and gastrointestinal bleeding.
  • Naproxen can increase the levels of lithium in the blood, which means there is a chance of lithium toxicity. 
  • Naproxen can interact with selective serotonin reuptake inhibitors (SSRIs) like sertraline to increase the risk of gastrointestinal bleeding because it affects platelet function. 
  • Naproxen can also increase the levels of methotrexate in the blood to cause its toxicity. 
  • After interacting with blood pressure medications, Naproxen can reduce their efficacy and increase blood pressure. 
  • Naproxen can interact with anticoagulant drugs like warfarin and increase the chance of bleeding. 

These are a few of the possible interactions, but not all of them. So, before taking Naproxen, you should consult your physicians. They will weigh the benefits and risks to provide you with the necessary dosages. 

NSAIDs abuse:

NSAIDs are drugs like ibuprofen, Naproxen and aspirin that are used to relieve pain, inflammation and fever. While they can provide effective relief from all these things, they can also cause serious adverse effects if misused. People tend to believe that if they have more pain so, taking more NSAIDs will solve the problem. This is a big mistake, as that's not how things work. Taking more than the recommended dosage is a common abuse issue. 

Chronic pain is quite painful, and people make the mistake of rushing to relieve pain. They take NSAIDs without the prescription of doctors. This also leads to the abuse of the medicine. Chronic pain is required to be looked at properly and have a tailored treatment because it's a severe condition. It can worsen the quality of life if not treated properly.

Therefore, people need to be responsible and use NSAIDs properly with guidance to not cause any kind of complications and abuse. Awareness about these medications' abuse is necessary to prevent people from abusing them.

Can I take tramadol and Naproxen together?

Yes, taking tramadol and Naproxen (Aleve) together can be considered for the management of pain in specific conditions. These situations arise when individual medications don't do their job effectively. However, these medications should be taken under the guidance of healthcare professionals. 

Tramadol is an opioid analgesic. It works by combining the opioid receptors in the brain or spinal cord. This helps in reducing the sensation of pain. It also inhibits the reuptake of serotonin and norepinephrine, which can also contribute to its analgesic effects.

Naproxen is an NSAID drug that works by blocking the production of prostaglandins, chemicals that cause pain and inflammation. For this reason, it is mainly used for anti-inflammatory purposes. 

The rational reason behind using these two medications together is to achieve the analgesic effect and cure the inflammation simultaneously. Tramadol provides the necessary pain relief due to opioids, while Naproxen helps reduce any inflammation associated with that pain. 

However, since these medications are this good, doctors must recommend them in theory. However, the practicality is always different, so doctors must be consulted before taking them.

Potential Risks of taking tramadol with Naproxen:

It is paramount to know the potential side effects of combining these medicines. Following are some of the possible risks:

  • When tramadol and Naproxen are taken together, then the risk of gastrointestinal bleeding and ulcers is increased significantly. 
  • They can cause drowsiness, dizziness and central nervous depression. It is recommended not to use machinery because it impairs the cognitive function. 
  • Respiratory depression is a medical name for slowed breathing. Since tramadol is an opioid, it can cause respiratory depression among people who have breathing problems. Naproxen can also cause this, so when you combine these two medications. The chances of respiratory depression increase significantly.
  • Tramadol and Naproxen can also interact with other drugs that you are taking. Therefore, it is essential to inform your doctor about all the medicines before taking them yourself.
  • Taking tramadol and Naproxen can increase the chances of overall side effects. They include nausea, constipation, headache, elevated blood pressure and gastrointestinal disturbances. 

These risks vary among people of different ages, health conditions, dosage levels, and durations of use. So, people must consult with physicians before taking these two medicines together. They can check their symptoms and medical history to help make a plan to relieve their pain. That plan needs to be followed to avoid risking side effects. 

Taking tramadol and Naproxen: Dosing Information.

A qualified doctor should recommend the dosing of these medicines. The doses depend on many factors, such as a person's medical history, pain severity, and overall health. Healthcare professionals recommend different dosages and durations for both tramadol and Naproxen. Tramadol is reported to be stronger than Naproxen. 

For instance, tramadol is often prescribed in doses from 50mg to 100mg, which must be taken every 4 to 6 hours to complete the daily recommended dosage of 400mg. On the flip side, Naproxen is prescribed in doses of 250mg to 500mg, which must be taken twice daily. However, the daily limit is 1250mg. 

It is important to emphasize that guidance from healthcare professionals is necessary if you are taking these medications. The exact amount depends entirely on the individual's medical history, current symptoms, and overall health. 


To summarize everything, tramadol and Naproxen can be taken together in certain situations. However, it must be done at the recommendation of healthcare professionals. These are highly effective drugs, but they are also very dangerous because they can cause a lot of severe side effects. 

Consulting your doctor is also necessary because these medications can interact with other medicines you might be taking, increasing the likelihood of these side effects. Therefore, the role of healthcare providers in using tramadol and Naproxen responsibly becomes crucial. Self-administration of these medications is strictly prohibited.