Taking Tramadol with Baclofen: What do you need to know?

Taking Tramadol with Baclofen: What do you need to know?

Tramadol with Baclofen


It is possible to take Tramadol and Baclofen together when doctors prescribe them and when they are taken at the proper time with exact recommended dosages. However, most healthcare professionals recommend not taking them together because Tramadol has serious side effects. Tramadol and Baclofen can interact with each other, and side effects like dizziness, drowsiness, and respiratory depression can occur in a patient. Therefore, please don't take them without medical supervision.

Tramadol is a painkiller used to treat pain after injury or surgery. Baclofen is a muscle relaxant. People may consider using them together when they are suffering from both conditions. However, they shouldn't do this without guidance from healthcare providers. Because of medical knowledge, healthcare professionals recommend the perfect dosages of both medicines. The benefits could outweigh the risks that way. 

What is Tramadol?


Tramadol is an opioid used to treat moderate to severe pain. It functions by combining with opioid receptors in the brain and spinal cord, reducing the sensation of pain. Tramadol is often used to treat chronic pain that occurs after operations and cancer. It comes in two formulations: IR (immediate release) and ER (extended release).   

Mechanism of action:

Tramadol has a dual mechanism of action because it not only acts on opioid receptors but non-opioid pathways as well. It works mainly by binding to opioid receptors in the brain or spinal cord. As a result, the sensation of pain is reduced effectively. Tramadol also inhibits the reuptake of serotonin and norepinephrine. These neurotransmitters are responsible for mood regulation, anxiety and perception of pain. So, increasing their level in the brain enhances the effects of pain relief. 

This contribution of Tramadol can also lead to increasingly severe side effects like respiratory depression and addiction problems. Overall, the mechanism is that it works on both opioid and non-opioid pathways of the brain and spinal cord. Consequently, the perception of pain reduces, and the potential risk of side effects increases. 

Side effects:

Like all other opioids, Tramadol also has the potential to cause tramadol side effects. The most common side effects of Tramadol are as follows;

  • Dry mouth
  • Fatigue
  • Headache
  • Constipation
  • Dizziness
  • Nausea and vomiting 

Moreover, some rare but severe side effects can also occur. They are:

  • Seizures
  • Respiratory depression
  • Dependence or addiction
  • Serotonin syndrome occurs when the brain has an excess of serotonin. Possible symptoms of this are agitation, fast heart rate, high blood pressure, and muscle stiffness. 

Tramadol interactions with other medications:

Following are the interactions of Tramadol with other medicines:

  • Tramadol with Baclofen increases the risk of severe side effects like respiratory depression, dizziness and drowsiness. 
  • Taking oxycodone with Tramadol can cause sedation and also tramadol depression.
  • Interaction between Tramadol and Tylenol (acetaminophen) Tramadol affects the liver if taken at higher dosages. 
  • Taking Tramadol with Advil (ibuprofen) causes Tramadol and increases the risk of gastrointestinal bleeding. 
  • Motrin (naproxen) and tramadol also causes gastrointestinal bleeding and ulceration. 
  • Tramadol interacts with Percocet and causes sedation & respiratory depression. 
  • Tramadol and metaxalone interaction causes sedation and drowsiness. 

As mentioned earlier, all of the medicines can cause side effects when taken with Tramadol. Therefore, Tramadol must consult with doctors before taking these medicines and stick to their schedule. 

Things to consider before taking Tramadol:

  • It is usually taken with or without food. 
  • Swallow the tablet whole. Don't chew or crush it. 
  • The dosages depend on several factors: the patient's medical history and pain severity.
  • Don't share your medicines with others.
  • Please don't take it any more than prescribed dosages.
  • Please don't take it with alcohol and other sedatives.
  • If patients miss a dose, take it when you remember. But if it's already time for the next one, only take one dosage. 
  • Please take it as the doctors prescribe it because higher dosages can cause dependency. 

What is Baclofen?


Baclofen is a muscle relaxant used to treat muscle stiffness and spasms that occur in conditions like muscle sclerosis and spinal cord injuries. It is taken orally as an injection or tablet. It acts on the spinal cord to decrease certain signals that cause muscle stiffness. 

Baclofen can also cause side effects like drowsiness, dizziness, nausea, constipation, and weakness. These are mild effects, but severe effects include allergy, hallucinations, and seizures. It can also interact with other medicines to cause risks. Therefore, Baclofen should only be taken under the guidance of professionals. 

Mechanism of Action:

Baclofen combines with GABBA-B receptors in the spinal cord. These receptors are responsible for releasing neurotransmitters that cause muscle contractions. Upon combining, a reduction in the activity of neurons occurs, causing muscle spasms and stiffness. 

Baclofen is also responsible for the release of norepinephrine, a neurotransmitter that helps the body respond to stress. The overall mechanism still needs to be fully understood by the researchers. However, it inevitably works in multiple pathways to reduce muscle spasms and stiffness. 

Side effects: 

Some of the most common side effects of Baclofen are:

  • Drowsiness and dizziness
  • Fatigue
  • Nausea and vomiting
  • Constipation
  • Headache
  • Urinary retention

The most severe side effects of Baclofen are as follows:

  • Seizures
  • Hallucinations
  • Allergic reactions
  • Respiratory depression

If you experience any side effects, it is mandatory to visit healthcare professionals for medical attention. They will provide guidelines on how to best manage the symptoms and take Baclofen. 

Things to consider before taking Baclofen:

The following points should be considered before taking Baclofen:

  • Take the medicine as prescribed by the healthcare professionals.
  • It can be taken with or without food, but it is recommended that it be taken with food so the stomach doesn't get upset. 
  • Swallow the tablets whole.
  • Do not stop taking Baclofen suddenly to avoid withdrawal symptoms. Contact your healthcare provider.
  • If you miss a dose, take it as soon as you remember. However, if the time for the next dose is already there, take only one dose. 
  • Store baclofen at room temperature.
  • Please keep it away from moisture and heat.
  • Do not share your medications with others.
  • Inform your doctor in case you experience any symptoms. 

Drug interaction of Tramadol with Baclofen: 

Tramadol is an opioid analgesic that works by binding to mu-opioid receptors in the brain or spinal cord. As a result, the perception of pain starts to go downwards. Tramadol also plays a major role in regulating pain and mood by reuptaking serotonin and norepinephrine.  

On the other hand, Baclofen is a gamma-aminobutyric acid (GABA) receptor that is reported to be a muscle relaxant. When Baclofen binds to GABA-B receptors in the brain or spinal cord, it reduces muscle spasticity. 

The research argues that Tramadol and other co-analges Tramadol have therapeutic applications, but dosage needs to be precise. Three professors experimented in 2008 on albino mice, combining Tramadol with ketamine and Baclofen, which increased the efficacy of opioids while reducing the side effects. The research authors added that more clinical studies must be tested before applying this. 

Potential dangers and side effects of combining the two medicines:

The interaction between the two drugs is a bit complex and can have negative implications like addiction and synergetic effects. It is reported that when they are taken together, the sedative effects increase. Consequently, drowsiness, dizziness and impaired cognitive function are the most common side effects that come to the surface. 

Moreover, taking Tramadol and Baclofen together increases Tramadol for respiratory depression. This severe side effect most likely happens in patients taking higher dosages and having breathing problems. These medications may also interact with other drugs like alcohol and benzodiazepines to cause more severe side effects. These medications should only be taken under the supervision of the doctors. Healthcare professionals regularly need to monitor the patients to ensure they don't suffer from respiratory depression, sedation or even cognitive impairment. 

Factors that may increase the risk of adverse effects:

  • Age is a factor, as older people are more sensitive to the sedative effects
  • Patients with impaired kidney or liver function
  • Use of other medications
  • History of seizures
  • History of mental health issues like depression


In conclusion, taking Tramadol with Baclofen is a risky task. Tramadol's interaction can cause common or even severe side effects. These effects include respiratory depression, seizures, constipation, drowsiness, dizziness etc. It also depends upon the patients' pre-existing medical problems. 

Therefore, it becomes a primary matter that people discuss their medical histories with their doctors to have the complete picture before determining the dosages. Patients should also be monitored to examine whether there are any signs of side effects. These two medications should only be taken under the guidance of professionals. 


Q: Is baclofen stronger than tramadol?

A: These two medicines should be compared because they serve different purposes. Tramadol is a pain killer used to treat post-surgery and injury pain. Baclofen is a muscle relaxant that reduces muscle stiffness. Both have side effects.

Q: What should you avoid while taking Baclofen?

A: Alcohol, antidepressants, abruptly stopping taking the medicine and driving any machinery should be avoided. 

Q: What other medicines should not be taken with Tramadol?

A: Serotonin-enhancing drugs, Tramadol, and benzodiazepines should be avoided.

Q: can i take baclofen with ibuprofen?

A: It has potential for interactions, so these should only be done under the guidance of professionals.

Q: What is Tramadol used to treat?

A: Tramadol is an opioid analgesic that is used to treat pain occurring post-operation and cancer.

Q: Can Baclofen and Tramadol be taken together?

A: Their interaction can cause many serious effects, so they should be taken only after a doctor's recommendation.